Mario Williams’ Houston homecoming comes at a time when the Bills could desperately use a good game from their defensive line — and a win.

Houston’s Arian Foster rushes for the third-most yards per game and looks to prey on his ex-teammate Williams and the rest of the league’s worst run defense, which gives up 6.0 yards per carry.

Even on their losing spree, the Bills are still just 1 1/2 games out of first place in the division. A win over the 6-1 Texans would go a long way in the standings … I just don’t see it.

Buffalo +10.5 at Houston — Houston

Denver at Cincinnati +3.5 — Denver*

Arizona +11 at Green Bay — Packers

Miami at Indianapolis +2.5 — Indianapolis

Baltimore at Cleveland +3.5 — Cleveland

Carolina +3.5 at Washington — Redskins

Detroit at Jacksonville +3.5 — Lions

Minnesota +5 at Seattle — Seattle

Tampa Bay +1.5 at Oakland — Tampa

Pittsburgh +3.5 at Giants — Giants

Dallas +4 at Atlanta — Atlanta

Philadelphia +3 at New Orleans — Saints

Standings (best bets):
DiCesare 56-49-5 (4-4)
Skurski 56-49-5 (3-4-1)
Sullivan 50-55-5 (3-4-1)
Graham 49-56-5 (2-5-1)
IAGS 45-60-5 (6-1-1)
Northrop 42-63-5 (2-5-1)
Gaughan 41-64-5 (4-3-1)

Last week:

Pats vs. St. Louis +7 (in London) — Pats
Pats 45-7. Win

Indianapolis +3.5 at Tennessee — Colts
Colts 19-13. Win

Jacksonville +17 at Green Bay — Jacksonville
Packers 24-14. Win

San Diego at Cleveland +2.5 — Cleveland
Browns 7-6. Win

Atlanta +2.5 at Philadelphia — Atlanta*
Falcons 30-17. Win

Seattle +2 at Detroit — Seattle
Lions 28-24. Loss

Miami +2 at Jets — Jets
Dolphins 30-9. Loss

Carolina +7.5 at Chicago — Bears
Bears 23-22. Loss

Washington +4.5 at Pittsburgh — Pittsburgh
Steelers 27-12. Win

Oakland +1.5 at Kansas City — Oakland
Raiders 26-16. Win

Giants at Dallas +1 — Giants
Giants 29-24. Win

New Orleans +6 at Denver — Denver
Broncos 34-14. Win

San Francisco at Arizona +7 — 49ers
49ers 24-3. Win

10-3